Joel Glover

Dr. Joel Gløver
Dept. of Physiology
Institute of Basic Medical Sciences
University of Oslo
joel.glover@medisin.uio.no
Tel +47 22 85 12 30

 

 

 

ACTIVITIES

 

In vivo imaging is an important tool for following the fate of tumor cells and potential tumor stem cells in animal models.  One of the goals of CAST is to develop labeling and imaging protocols that facilitate non-invasive in vivo cell tracking at the highest possible spatial resolution. 

 

We are currently developing protocols for labeling primary tumor cells and tumor cell lines with superparamagnetic iron oxide (SPIO) beads. We are also testing the differentiation and behavior of SPIO-labeled cells both in vitro, using conventional microscopic techniques, and in vivo, using small animal MRI.  High-resolution imaging will facilitate the localization of early metastatic events and thereby provide an opportunity to assess the cellular characteristics of the cells that seed them, a potential route towards identifying tumor stem cells in action.

 

 

 


GROUP MEMBERS

active in CAST:

 

Doreen Leung, Post doc

Jean-Luc Boulland, Post doc

kristin Andersen, Post doc

Mrinal Joel, PhD student

Susanne Ström, Post doc

International consultant:

Scott Fraser, California Institute of Technology

 


 
 

SELECTED PUBLICATIONS


Sigurjonsson OE, Perreault MC, Egeland T, Glover JC. (2005) Adult human hematopoietic stem cells produce neurons efficiently in the regenerating chicken embryo spinal cord.  PNAS 102:5227-5232.

 

Glover JC, Renaud J-S, Rijli F. (2006) Retinoic acid and hindbrain patterning. J. Neurobiol 66:705-25.

 

Glover JC, Renaud J-S, Lampe X, Rijli F. (2006) Hindbrain development and retinoids. In: Nuclear Receptors in Development, Advances in Developmental Biology, volume 16, pp. ed. Reshma Taneja, Elsevier, San Diego, CA.

 

Perreault M-C, Bernier AP, Renaud J-S, Roux S, Glover JC. (2006) C fragment of tetanus toxin hybrid proteins evaluated for muscle-specific transsynaptic mapping of spinal motor circuitry in the newborn mouse. Neuroscience 141:803-821

 

Momose-Sato Y, Glover JC, Sato K. (2006) Development of functional synaptic connections in the auditory system visualized with optical recording: Afferent-evoked activity is present from early stages. J. Neurophysiol. 96:1949-1962.

 

Hirsch MR, Glover JC, Dufour H, Brunet J-F, Goridis C (2007). Forced expression of Phox2 homeodomain transcription factors induces a branchio-visceromotor axonal phenotype. Dev. Biol. 303:687-702.

 

Díaz, C., Pasqualetti, M., Renaud JS, Rijli, F. and J. C. Glover (2007) Fate-mapping the mammalian hindbrain: Segmental origins of vestibular projection neurons assessed using rhombomere-specific Hoxa2 enhancer elements in the mouse embryo. J. Neurosci. 27:9670-9681.

 

Glover JC (2008) Can we use human embryonic stem cells to treat brain and spinal cord injury and disease? In: Stem Cells, Human Embryos and Ethics: Interdisciplinary Perspectives, ed. Lars Østnor, Springer.

 

Glover JC, Sato K, Momose-Sato Y (2008) Using voltage-sensitive dye recording to image the functional development of neuronal circuits in vertebrate embryos. Dev Neurobiol. 68:804-816

 

Halasi G, Kasumacic N, Egeland T, Glover JC. Neuronal differentiation and concomitant hematopoietic marker downregulation by human bone marrow-derived CD34+ cells in vivo. Soc Neurosci Abstr 38, 2008.

 

Glover JC, Boulland JL, Halasi G, Kasumacic N. Chimeric animal models in human stem cell biology. ILAR J. 2009;51(1):62-73.

 

 

 

 

 

 

 

 

 

 

 

 

Joel Glover laboratory