intro

February 2015

Dissertation

 

Kaja Lund - næringsstipendiat (commercial PhD)

is defending her thesis Friday 27th at 13.00; Runde auditorium (R-105), Domus Medica tilbygg, Sognsvannsveien 9, Oslo.

Cand. Scient Kaja Lund ved Institutt for klinisk medisin and SFI-CAST vil forsvare sin avhandling for graden ph.d. (philosophiae doctor): Aspects of the epithelial-to-mesenchymal transition in carcinoma cancer. Studies in pancreatic cancer cell lines.

http://www.med.uio.no/klinmed/forskning/aktuelt/arrangementer/disputaser/2015/lund-kaja.html

 

Prøveforelesning: Kaja Lund

Cand. Scient Kaja Lund ved Institutt for klinisk medisin and SFI-CAST avholder prøveforelesning over oppgitt emne: "Epigenetics in EMT and Cancer".

 
 

December 2014

Tankyrase specific inhibitor G007-LK licensed to Millipore KGaA

 

The Tankyrase specific inhibitor G007-LK has been licensed as a research tool to Merck/Millipore KgaA. G007-LK has unique specificity to the catalytic PARP domain of tankyrase1/2 and a favorable PK/PD that make it an excellent research tool for in vitro and in vivo studies.

 
 

November 2014

Patent on tankyrase specific inhibitors granted in US jurisdiction

 

The patent “Triazole derivatives as Wnt signaling pathway inhibitors” (EP2649063 A1) that has been filed by SFI-CAST researchers Daniel Holsworth, Jo Waaler, Ondrej Machon, Andrey Edward Voronkov and Stefan Krauss has been granted in the US jurisdiction.

 
 

October 2014

Prize for best poster to a PhD student from SFI-CAST

 

PhD student Tor Espen Torvaldsen from Harald Stenmark's group, was honored with a prize for the best poster presentation at the international EMBO Workshop on “Wnt Signalling - Stem cells, Development and Disease”, held in Broome, Western Australia, from the 6th-9th of October. Tor Espen Torvaldsen received a prize for the best poster with the title "Elucidating the molecular mechanisms and dynamics of G007-LK-induced formation of beta-catenin containing destruction complexes".

 
 

April 2014

Annual report SFI-CAST 2013

 

The Annual report for 2013 is now published

Annual Report 2013 

 
 

February 2014

Joint publication between SFI-CAST researchers on the effect of tankyrase inhibition in osteosarcoma cells

 

Wnt/â-catenin is a major regulator of stem cell self-renewal and differentiation and this signaling pathway is aberrantly activated in a several cancers, including osteosarcoma. The publication demonstrates for the first time that tankyrase inhibition triggers reduced cell growth, differentiation and an induction of let-7 miRNA of osteosarcoma cells. Tankyrase inhibition may open for novel therapeutic strategies in the treatment of malignant osteosarcomas.
The paper was published in Cancer Med 2014 Feb;3(1):36-46. PMID:24403055

 
 

January 2014

First Industry-Industry collaboration in SFI-CAST result in joint publication

 

The novel EpCAM-targeting monoclonal antibody 3–17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines

Link to the article published in mAbs

 
 

December

Dagens Medisin: Helseprioriteringene blir enda mer krevende

 

Dagens Medisin 3.Desember: Helseprioriteringene blir enda mer krevende

Leder for Norsk Kreftgenomikkonsortium, Ola Myklebost, (nestleder av SFI-CAST) fant nylig en bestemt mutasjon hos lungekreftpasienter som det var mulig å gi leukemi-legemidler mot. 

 
 

November

SFI-CAST workshop 22nd of November

 

SFI-CAST WORKSHOP at HOLMENKOLLEN PARK HOTEL

09.00 - 15.30

 
 

8. nov. 2013

Dissertation and trial lecture: Jo Waaler - Kreftbehandling og kreftbiologi

 

Trial lecture

GSK3β as an integrator of multiple signaling pathways during normal development and cancer

8th of November 09.15, Seminarrom 1 B2.U001, Oslo universitetssykehus HF, Rikshospitalet

Disputas/dissertation

M.Sc. Jo Waaler: Development of specific tankyrase inhibitors for attenuating canonical Wnt/β-catenin signaling.

8th of November 11.15, Seminarrom 1 B2.U001, Oslo universitetssykehus HF, Rikshospitalet

 
 

14-15 October 2013

The 10th Annual Norwegian Stem Cell Networking Meeting, Oslo

 

The 10th Annual Norwegian Stem Cell Networking Meeting will be held on October 14-15

For more information visit NCS

 
 

August 2013

Gunhild Mælandsmo's latest paper to be published in BJC

 

In this prospective study, covered in "Clinical significance of disseminated tumour cells in non-small cell lung cancer", Mælandsmo et al. have investigated the presence of DTCs in the bone marrow collected from 296 patients with stages I–IIIA NSCLC undergoing curatively intended surgery, using both IMS and ICC. In addition, 81 bone marrow samples from healthy volunteers were investigated using IMS.

They have compared the results from the two methods, investigated the associations with clinicopathological parameters and examined the prognostic impact of the presence of DTCs.

This paper has been pre-published in the British Journal of Cancer's advanced online publication 13th of August 2013. 

 
 

14th - 16th July, 2013

Wnt Symposium 2013, Heidelberg

 
 

SFI-CAST

Available Positions

 

There are no available positions at the moment.